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Metachromatic Leukodystrophy - 25 Studies Found

Status Study
Active, not recruiting Study Name: The Natural History of Metachromatic Leukodystrophy
Condition: Metachromatic Leukodystrophy
Date: 2008-03-11
Completed Study Name: Multicenter Study of HGT-1110 Administered Intrathecally in Children With Metachromatic Leukodystrophy (MLD)
Condition: Metachromatic Leukodystrophy (MLD)
Date: 2011-12-14
Interventions: Biological: Recombinant human arylsulfatase A 6 patients treated with HGT-1110 EOW by IT injection
Completed Study Name: Effect of Warfarin in the Treatment of Metachromatic Leukodystrophy
Condition: Metachromatic Leukodystrophy
Date: 2008-05-21
Interventions: Drug: Warfarin Oral administration (QD), variable dosage: patients will undergo blood test for PT/INR at
Completed Study Name: Efficacy METAZYM for the Treatment Metachromatic Leukodystrophy Treated With Hematopoietic Stem Cell Transplantation
Condition: Metachromatic Leukodystrophy
Date: 2011-02-23
Interventions: Drug: rhARSA intravenous infusion 100U/kg every other week for 18 months
Recruiting Study Name: Intracerebral Gene Therapy for Children With Early Onset Forms of Metachromatic Leukodystrophy
Condition: Metachromatic Leukodystrophy
Date: 2013-01-28
Interventions: Genetic: intracerebral administration of AAVrh.10cuARSA
Completed Study Name: Long-term Metazym Treatment of Patients With Late Infantile Metachromatic Leukodystrophy (MLD)
Condition: Late Infantile Metachromatic Leukodystrophy
Date: 2008-02-29
Interventions: Biological: Recombinant human Arylsulfatase A (rhASA) intravenous infusion, every other week for 26 week
Completed Study Name: Imaging Study of the White Matter Lesions in Children With Metachromatic Leucodystrophy
Condition: Late Infantile Metachromatic Leukodystrophy
Date: 2011-03-09
Interventions: Other: High-field MRI (3 Teslas)

Terminated Study Name: Open-Label Extension Study of Recombinant Human Arylsulfatase A (HGT-1111) in Late Infantile MLD
Condition: Late Infantile Metachromatic Leukodystrophy
Date: 2008-05-19
Interventions: Drug: HGT-1111 Patients currently dosed with 100 U/kg or 200 U/kg will continue this treatment. Patients
Enrolling by invitation Study Name: Open-Label Extension Study Evaluating Safety and Efficacy of HGT-1110 in Patients With Metachromatic Leukodystrophy
Condition: Metachromatic Leukodystrophy (MLD)
Date: 2013-06-20
Interventions:
  • Biological: Recombinant human arylsulfatase A

Completed Study Name: Metazym for the Treatment of Patients With Late Infantile Metachromatic Leukodystrophy (MLD)
Condition: Metachromatic Leukodystrophy (MLD)
Date: 2007-01-04
Interventions: Drug: rhASA intravenous infusion 25 U/kg,50 U/kg, 100U/kg or 200 U/kg every other week for 26 weeks
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