Brain tumor-polyposis syndrome (BTPS) is a condition caused by a genetic predisposition in which the patient suffers from two comorbidities- brain tumor and the formation of polyps in the gastrointestinal tract. It is also called Turcot Syndrome. The condition is classified into Type I and Type II based on its clinical manifestation, manner of inheritance, and type of mutation in underlying genes.
Treatment for BTPS
Being an illness caused by a genetic abnormality, there is no cure yet for brain tumor-polyposis syndrome. All treatments are aimed at medically managing the patient’s conditions. For that, it is important to consider whether the ailment is a type I or a type II category. Medical care often starts with an early diagnosis and follows up with an accurate prognosis. Some treatment procedures include:
1. Surgical Resection of Tumor: The basic medical procedure to prevent the development of a tumor into a malignant one is its surgical removal. This option always depends upon the location and type of the tumor as well as the patient’s age and physical condition.
2. Colorectal Surgery: The polyps formed in the intestinal tract may be harmless in the beginning. To prevent them from turning cancerous, colectomy, i.e., complete removal of the affected portion of the large intestine, is the option.
3. Chemotherapy & Radiation: In Turcot syndrome patients, chemotherapy and radiation are needed for treating cancer.
4. More important, awareness of the patient and family regarding the general nature of the ailment is required. Children of a person identified with BTPS have a very high chance of inheriting the disease.
5. DNA testing can confirm the presence of mutated genes causing the condition. Those individuals should be closely monitored from childhood for brain tumor-polyposis syndrome to avoid the risk of late diagnosis.
Diarrhea,Constipation,Abdominal pain,Neurological problems,Cancerous tumor outside the colon,Skin problems,Problems with eyesight, etc
An inherited genetic disorder,Primary brain tumor with polyps in gastrointestinal tract,Glioblastoma,Medulloblastoma,Gastrointestinal polyps
Afinitor (Everolimus),Afinitor Disperz (Everolimus),Avastin (Bevacizumab),Belzutifan,Lomustine,Zirabev (Bevacizumab)