About dupuy's syndrome
What is dupuy's syndrome?
Frey syndrome is a rare disorder that most often occurs as a result of surgery in the area near the parotid glands. The parotid glands are the largest salivary glands in the body located just below the ears on either side of the face. The main symptoms of Frey syndrome are undesirable sweating and flushing occurring on the cheek, temple (temporal region), or behind the ears (retroauricular region) after eating certain foods, especially those that produce a strong salivary response. Symptoms are often mild and well-tolerated. In some cases, symptoms may be more severe and therapy may be necessary. The exact underlying mechanisms that cause Frey syndrome are not fully understood. Frey syndrome most often occurs as a complication of surgery to the area of the face near the parotid glands.
What are the symptoms for dupuy's syndrome?
Thickening of the skin on the palm of your hand symptom was found in the dupuy's syndrome condition
In later stages of Dupuytren's contracture, cords of tissue form under the skin on your palm and can extend up to your fingers. As these cords tighten, your fingers might be pulled toward your palm, sometimes severely.
The two fingers farthest from the thumb are most commonly affected, though the middle finger also can be involved. Only rarely are the thumb and index finger affected. Dupuytren's contracture can occur in both hands, though one hand is usually affected more severely.
What are the causes for dupuy's syndrome?
Doctors don't know what causes Dupuytren's contracture. There's no evidence that hand injuries or occupations that involve vibrations to the hands cause the condition.
What are the treatments for dupuy's syndrome?
If the disease progresses slowly, causes no pain and has little impact on your ability to use your hands for everyday tasks, you might not need treatment. Instead, you can wait and see if Dupuytren's contracture progresses. You may wish to follow the progression with a tabletop test, which you can do on your own.
Treatment involves removing or breaking apart the cords that are pulling your fingers toward your palm. This can be done in several ways. The choice of procedure depends on the severity of your symptoms and other health problems you may have.
Needling
This technique uses a needle, inserted through your skin, to puncture and break the cord of tissue that's contracting a finger. Contractures often recur but the procedure can be repeated.
The main advantages of the needling technique are that there is no incision, it can be done on several fingers at the same time, and usually very little physical therapy is needed afterward. The main disadvantage is that it can't be used in some places in the finger because it could damage a nerve or tendon.
Enzyme injections
Injecting a type of enzyme into the taut cord in your palm can soften and weaken it — allowing your doctor to later manipulate your hand in an attempt to break the cord and straighten your fingers. The FDA has approved collagenase Clostridium histolyticum (Xiaflex) for this purpose. The advantages and disadvantages of the enzyme injection are similar to needling. Enzyme injections are not offered at all medical institutions.
Surgery
Another option for people with advanced disease, limited function and progressing disease is to surgically remove the tissue in your palm affected by the disease. The main advantage to surgery is that it results in a more complete and longer-lasting release than that provided by the needle or enzyme methods. The main disadvantages are that physical therapy is usually needed after surgery, and recovery can take longer.
In some severe cases, especially if surgery has failed to correct the problem, surgeons remove all the tissue likely to be affected by Dupuytren's contracture, including the attached skin. In these cases a skin graft is needed to cover the open wound. This surgery is the most invasive option and has the longest recovery time. People usually require months of intensive physical therapy afterward.
What are the risk factors for dupuy's syndrome?
A number of factors are believed to increase your risk of the disease, including:
- Age. Dupuytren's contracture occurs most commonly after the age of 50.
- Sex. Men are more likely to develop Dupuytren's and to have more severe contractures than are women.
- Ancestry. People of Northern European descent are at higher risk of the disease.
- Family history. Dupuytren's contracture often runs in families.
- Tobacco and alcohol use. Smoking is associated with an increased risk of Dupuytren's contracture, perhaps because of microscopic changes within blood vessels caused by smoking. Alcohol intake also is associated with Dupuytren's.
- Diabetes. People with diabetes are reported to have an increased risk of Dupuytren's contracture.
Is there a cure/medications for dupuy's syndrome?
Dupuytren's syndrome is a hand deformity that usually develops over the years. The condition affects a layer of tissue that lies under the skin of your palm.
Treatment involves removing or breaking apart the cords that are pulling your fingers toward your palm. This can be done in several ways. The choice of procedure depends on the severity of your symptoms and other health problems you may have.
1. Needling: This technique uses a needle inserted through your skin, to puncture and break the cord of tissue that's contracting a finger. Contractures often recur, but the procedure can be repeated.
2. Enzyme injections: Injecting a type of enzyme into the taut cord in your palm can soften and weaken it — allowing your doctor to later manipulate your hand in an attempt to break the cord and straighten your fingers. The FDA has approved the collagenase Clostridium histolyticum (Xiaflex) for this purpose. The advantages and disadvantages of the enzyme injection are similar to needling. Enzyme injections are not offered at all medical institutions.
3. Surgery: Another option for people with advanced disease, limited function and progressing disease is to surgically remove the tissue in your palm affected by the disease.
Symptoms
Thickening of the skin on the palm of your hand
Conditions
The skin might appear puckered as knots (nodules) of hard tissue begin to form on your palm,These nodules might feel tender to the touch, but they’re usually not painful
Drugs
Needling,Enzyme injections surgery