Primary empty sella syndrome
The exact cause of primary empty sella syndrome isn’t clear. It may be related to a birth defect in the diaphragma sellae, a membrane that covers the sella turcica. Some people are born with a small tear in the diaphragma sellae, which can cause CSF to leak into the sella turcica. Doctors aren’t sure whether this is a direct cause of empty sella syndrome or simply a risk factor.
According to the National Organization for Rare Disorders, empty sella syndrome affects about four times as many women as it does men. Most women with empty sella syndrome tend to be middle-aged, obese, and have high blood pressure. However, most cases of empty sella syndrome go undiagnosed due to their lack of symptoms, so it’s hard to say whether gender, obesity, age, or blood pressure are true risk factors.