Oxalosis is a rare inherited metabolic disorder caused by the overproduction of oxalate, which leads to the accumulation of an excessive amount of calcium oxalate. It is caused by a deficiency of enzymes involved in the metabolism of glyoxylate. Primarily calcium oxalate accumulates in the kidneys causing kidney stones and eventually leading to kidney failure. Followed by renal failure, the accumulation occurs first in blood and then in the eyes, bones, skin, muscles, blood vessels, heart, and other organs. There are three types, each caused by different genetic mutations.
1. Large Fluid Consumption: It helps dilute the urine reducing crystallization of oxalate, through frequent urination.
2. Large Daily Doses of Vitamin B6
3. Magnesium Supplements
4. Oxalate-Reduced Diet: Tomato, spinach, rhubarb, almonds, cashews, miso soup, grits, baked potatoes with skin, beets, cocoa powder, okra, bran cereals, shredded wheat cereals, french fries, raspberries, stevia sweeteners, sweet potatoes are rich in oxalate and must be avoided.
5. Urinary Tract Endoscopy: Kidney stones of the size of up to 2 centimeters can be removed by ureteroscopy.
6. Renal dialysis: It is a procedure that allows the removal of excessive oxalate when the kidney fails to excrete oxalate crystals. A limitation of dialysis is its incapability to keep pace with the production of oxalate.
7. Kidney Transplant: Renal failure is addressed by a kidney transplant. However, recurrent failure leads to graft failure upon repeated transplantation.
8. Kidney-Liver Transplant: After the confirmation of oxalosis due to a deficiency of relevant hepatic enzymes, liver transplantation along with kidney transplantation, followed by first renal failure, is a better option.
Severe or sudden back pain,Pain in the area below the ribs on the back (flank) that doesn't go away,Blood in the urine,Frequent urge to urinate,Pain when urinating,Chills or fever
Lumasiran (Oxlumo),Prescription doses of vitamin B-6,Oral preparations of phosphates and citrate,Thiazide diuretics, also may be considered, depending on which other abnormalities are present in your urine