About premature aging syndrome

What is premature aging syndrome?

Branchio-oculo-facial syndrome (BOFS) is a very rare genetic disorder that is apparent at birth (congenital). As of 2004, only about 50 cases of BOFS had been reported in the medical literature. The symptoms of most BOFS patients include the proliferation of blood vessels (hemangiomatous) in the lower neck or upper chest, low birth weight, retarded growth and some mental retardation. BOFS is characterized by the presence of a pseudocleft of the upper lip resembling a poorly repaired cleft lip, a malformed nose with a broad bridge and flattened tip, blockage of the tear ducts (lacrimal duct obstruction), malformed ears, lumps in the area of the neck or collarbone (branchial cleft sinuses) and/or linear skin lesions behind the ears. Often, affected individuals may have burn-like lesions behind the ears. However, even among the cases so far reported, the symptoms may vary from mild to severe forms. The disorder is inherited as an autosomal dominant trait.

What are the symptoms for premature aging syndrome?

Retarded growth symptom was found in the premature aging syndrome condition

The aging process looks different for everyone, but there are certain signs of aging that are considered “premature” if you notice them before you turn 35.

Sun spots

Sun spots, also called age spots and liver spots, are flat spots on your skin caused by years of sun exposure.

These hyper-pigmented spots may develop on your face, the back of your hands, or your forearms.

They tend to appear at or after age 40. People with fairer skin, like Fitzpatrick type 1 and 2, may see these sun spot developments earlier.

Gaunt hands

Over time, the top layers of your skin become thinner and contain fewer structuring proteins, such as collagen, that give your skin its shape.

Your hands may start to appear more veiny, thin, and prone to wrinkles as a result.

There’s no objective metric for when hands start looking older, but most people tend to notice it during their late 30s and early 40s.

Inflammation or hyperpigmentation along chest

Many people develop patchy discoloration on their chest as they get older.

Similar to sunspots, these areas of differing pigment can be caused by damage to your cells from sun exposure.

This kind of hyperpigmentation isn’t always connected to aging. It can be the result of eczema or other skin conditions that damage the melanin cells in your skin.

There isn’t an average age of when this skin condition typically appears.

Dry or itchy skin

Dry or itchy skin (xerosis cutis) may happen more frequently over time. That’s because thinning skin is more susceptible to dehydration.

You may notice your skin becoming drier and more prone to flaking as you near your 40s.

Wrinkles or sagging

As you enter your 30s, your skin slows down its production of collagen, the protein that gives your skin its shape. Collagen is what helps your skin bounce back and stay plump.

With less collagen in the skin, it’s easier for visible wrinkles and sagging to occur. You might notice this happening more in areas around frequently used muscles, like the forehead, or where you’re more exposed to the sun.

The age when people first notice wrinkles varies, with little standard for when it’s “premature.”

And sometimes aging may not even be responsible. It could simply be dirt or dehydration.

Hair loss

Hair loss happens as the stem cells that trigger new hair growth in your hair follicles die off.

Hormone changes, environmental factors, genetics, and your diet all play a role in how quickly this happens.

Up to 40 percent of women over age 70 experience hair loss. Men experience it earlier, with 50 percent seeing hair loss after age 50.

What are the causes for premature aging syndrome?

There are a couple of different factors that have a direct effect on how quickly these signs appear on your body.


The toxins in cigarette smoke expose your skin to oxidative stress. This causes dryness, wrinkles, and other signs of premature aging.

Sun exposure and tanning

Tanning beds and exposure to the sun penetrate your skin with UV rays. These rays damage the DNA in your skin cells, causing wrinkles.


There are some very rare genetic conditions that can cause you to show signs of aging in childhood and early puberty. These conditions are called progeria.

Werner syndrome affects 1 in 1 million people. It causes wrinkled skin, graying hair, and balding to develop between 13 and 30 years old.

Hutchinson-Gilford syndrome is an even rarer condition, affecting 1 in 8 million babies.

Children with this syndrome don’t grow as quickly as others in their age group. They also experience thin limbs and baldness. The average life expectancy for children living with Hutchinson-Gilford syndrome is 13 years.

What are the treatments for premature aging syndrome?

Once you notice the signs of aging, you can take steps to address the way your body is changing — or allow nature to take its course.

There isn’t a right or wrong way to age, and whatever you choose to do with your body is entirely up to you.

If you have sunspots

If you notice sunspots, start by seeing a dermatologist to rule out other skin conditions.

Once you know for sure what you’re dealing with, consider what lifestyle changes you can make.

Wear sunscreen with at least 30 SPF daily to protect yourself from UV rays, and reduce direct exposure to the sun whenever possible. Covering up when you go outside can help prevent further spots from appearing.

You may also try treating the sunspots topically to see if they fade. Aloe vera, vitamin C, and products containing alpha hydroxy acid may help treat sunspots.

If those aren’t effective, clinical treatment for sunspots includes intense pulsed light therapy, cryotherapy, and chemical peels.

If you have gaunt hands

If your hands appear to be gaunt, with translucent, fragile skin and visible veins, start moisturizing them regularly.

It may be time to try a new product that locks hydration in to your skin barrier. You may also want to apply sunscreen with at least 30 SPF to your hands.

If your hands are regularly exposed to chemicals and pollutants through the work that you do or your household chores, it might not be possible to stop your exposure to those things completely.

Instead, make small changes — like wearing gloves when you wash the dishes or weed your garden.

If you’re concerned with how your hands look, speak to a dermatologist.

Clinical treatments for hands that have aged include chemical peels, dermal fillers, and laser treatment.

If you have inflammation or hyperpigmentation

If you have discoloration on your chest, start protecting that area of your body from the sun whenever possible.

Use sunscreen with at least 30 SPF each day, and pay careful attention to covering the parts of your skin that have been damaged.

Moisturize the area frequently and try to find a lotion with vitamin C or retinoids.

There are products that a doctor can prescribe to treat hyperpigmentation in your chest area. Mild steroids and bleaching agents can fade the look of hyperpigmentation over time.

If you have dry or itchy skin

If your skin is flaky, dry, and itchy, you may want to speak with a dermatologist and rule out any other health conditions.

Once you know that your dry skin is a sign of aging and not a symptom of something else, start focusing on lifestyle factors.

Drink more water to maintain hydration throughout your body and your skin. Take shorter showers using lukewarm water.

Determine if the dryness is a result of your skin type or if it’s actually dehydrated, as the treatments for both differ.

Then find a moisturizer that works for you and apply it daily.

If switching up your routine at home doesn’t work, speak to a doctor about a prescription moisturizer that has stronger ingredients for protecting your skin.

If you have wrinkles or sagging skin

If your skin is sagging or you notice wrinkles, there are several things you can do.

Start by protecting your skin every day with a sunscreen with at least 30 SPF. Limit your sun exposure by wearing hats with a brim and loose clothing that covers your limbs.

If you smoke, quitting can help prevent further skin damage.

Drink water and moisturize your skin each day. Cosmetics with green tea extracts, vitamin A, vitamin C, retinoids, and anti-oxidants may help.

If you’d like to go the clinical route, procedures like Botox and dermal fillers can make your skin appear less wrinkled and more full or lifted.

If you have hair loss

If your hair is falling out or growing thinner, consider purchasing a shampoo and conditioner product meant to address the issue.

Make sure your diet is full of nutritious food that nourishes your hair. Consider adding a multivitamin or vitamin supplement to help your body make keratin.

Products for hair loss are different for cisgender men and women.

Rogaine (minoxidil) and Propecia (finasteride) are popular over-the-counter treatments.

What are the risk factors for premature aging syndrome?

Several lifestyle habits can contribute to how quickly your body shows signs of aging, even if they aren’t a primary cause.

Sleep habits

Sleep gives your body an opportunity to refresh and regenerate cells.

At least one small study has indicated that poor sleep quality is connected to increased signs of aging and a diminished skin barrier function.


Some researchTrusted Source suggests that eating a diet high in sugar and refined carbohydrates can damage your skin over time.

Alcohol and caffeine intake

Drinking alcohol excessively dehydrates your body. Over time, this dehydration can cause your skin to sag and lose its shape.

Caffeine may have a similar effect, although there’s conflicting research about if daily coffee consumption causes wrinkles.


Pigment spots and wrinkles can be triggered or worsened by environmental pollutants.

Since your skin comes into direct contact with the air around you, your skin barrier is being subjected to the toxins and pollutants in your daily environment.


A stressful lifestyle can trigger an inflammatory response in your body, as well as hurt your sleep habits. Stress hormones and inflammation can age your body faster

Is there a cure/medications for premature aging syndrome?

You can’t stop aging completely — and that’s a good thing.

Experiences come with age, and there are times when our skin or our body will reflect that.

When it comes to slowing the signs you don’t like, it’s all about prevention and giving your cells a boost through products or lifestyle changes.

In some cases, taking care of your skin can allow for a healing process that restores some of your skin’s appearance and restores a bit of its structure.

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