About purpura, thrombotic thrombocytopenic
What is purpura, thrombotic thrombocytopenic?
Thrombotic thrombocytopenia purpura (TTP) is a rare, serious blood disease. Major symptoms may include a severe decrease in the number of blood platelets (thrombocytopenia), abnormal destruction of red blood cells (hemolytic anemia), and disturbances in the nervous system. Kidney dysfunction and fever are also common. The exact cause of thrombotic thrombocytopenic purpura is unknown.
What are the symptoms for purpura, thrombotic thrombocytopenic?
Bleeding in mucus membranes symptom was found in the purpura, thrombotic thrombocytopenic condition
If you have TTP, you might notice these skin-related symptoms:
- You might have bruises that are purplish in color and have no obvious cause. These marks, called purpura, are part of what gives this condition its name.
- You might also have tiny red or purple spots that could look like a rash.
- Your skin may turn yellowish, which is called jaundice.
- Your skin may look pale.
You might also have other symptoms, such as:
In very serious cases, a stroke, major internal bleeding, or a Coma can occur.
What are the causes for purpura, thrombotic thrombocytopenic?
TTP may be either inherited or acquired.
There’s an inherited form of TTP that transmits as an autosomal recessive trait. This means that both parents of an affected individual must carry a copy of the abnormal gene.
The parents don’t usually have symptoms of TTP.
This genetic form of TTP results from a mutation in the ADAMTS13 gene. This gene plays a role in the production of an enzyme that causes your blood to clot normally.
Enzymes are special proteins that increase the rate of metabolic chemical reactions. Abnormal clotting occurs when the ADAMTS13 enzyme isn’t present.
In other cases, your body mistakenly produces proteins that interfere with the ADAMTS13 enzyme’s job. This is known as acquired TTP.
You can get acquired TTP in a variety of ways. You can develop it if you have HIV, for example. You can also develop it after certain medical procedures, such as a blood and marrow stem cell transplant and surgery.
In some cases, TTP can develop during pregnancy or if you have cancer or an infection.
Some medications can lead to the development of TTP. These include:
- hormone therapy
- estrogen, as used in birth control or hormone therapy
- cyclosporine (Neoral, Sandimmune), an immunosuppressant drug
What are the risk factors for purpura, thrombotic thrombocytopenic?
Thrombotic thrombocytopenic purpura is a rare condition that leads to blood clots to build small blood vessels across the course of the body. Clots like these can result in severe medical issues if they end up blocking blood vessels and restrict the flow of blood to organs like the brain, kidneys and the heart.
A protein of ADAMTS13 enzyme in the blood plays a role in blood clotting. An inadequacy in the ADAMTS13 gene causes overactive clotting of blood. As platelets are necessary for clotting and an excessive amount of platelets are used in clotting, there aren’t enough left to clot when one gets a cut. This will cause you to bleed out more than usual.
5. Bone marrow transplantations
7. Cyclosporine A