Subacute cerebellar degeneration (SCD) is characterized by the degradation of the brain region responsible for muscular coordination and balance (the cerebellum). Less frequently, the region linking the spinal cord to the brain may be implicated (the medulla oblongata, the cerebral cortex, and the brain stem). SCD is classified into two types: 1) paraneoplastic cerebellar degeneration, which sometimes accompanies a cancer diagnosis, and 2) alcoholic or nutritional cerebellar degeneration, which is caused by a shortage of vitamin B-1 (thiamine). These two categories have similar symptoms but not the same underlying cause.
1. Diagnosis and treatment of the underlying cancer are standard therapeutic treatments for paraneoplastic cerebellar degeneration. Prompt tumor excision, chemotherapy, and/or radiation may be effective and help patients lessen discomfort.
2. Adjuvant glucocorticoid therapy, such as methylprednisolone, and immunotherapy with effective T cell suppression, such as rituximab and tacrolimus, may be difficult to achieve. However, in isolated cases, both rituximab and tacrolimus have been reported to help stabilize symptom progression in individuals with paraneoplastic cerebellar degeneration.
3. Thiamine is given combined with other B vitamins to treat alcoholic/nutritional cerebellar degeneration, and usually relieves the disease if the patient quits consuming alcohol and resumes a normal diet.
4. Physical treatment with an emphasis on strength, balance, and gait balance can assist individuals with increasing symptoms to regain function and avoid long-term disability.
5. Occupational therapy can focus mostly on activities of daily life and dysphagia rehabilitation.
Weakened muscle coordination, Problems in the articulation of speech,Difficulty in swallowing,Diplopia,Dizziness,Tremors,Problems with cognitive and emotional regulation