Usually, faulty modifications (mutations) in the EZH2 gene result in Wallenberg syndrome. The EZH2 gene functions wrongly as a result of these detrimental alterations. The EZH2 gene has the ability to methylate, or switch on and off, other genes. The fact that Wallenberg syndrome affects numerous body systems is due to the influence of the EZH2 gene on the operation of numerous other genes. However, it is unknown how these modifications result in the precise Wallenberg syndrome symptoms. Some Wallenberg syndrome patients do not have an EZH2 gene mutation.
WS has an autosomal dominant inheritance pattern. When a certain condition can be brought on by a single defective gene, this is known as a dominant genetic disorder. The defective gene is inherited from an affected parent in roughly 50% of cases. One of the EZH2 genes in the affected person experiences a fresh (de novo) modification in the other half. Each pregnancy has a 50% probability of transferring the non-functioning gene from an afflicted parent to the fetus. Both men and women are equally prone to get this condition.
Treatment for Wallenberg syndrome
1. To provide the patient with the best chance of recovery, treating Wallenberg syndrome involves a quick reaction and well-coordinated team effort including clinicians, nurses, and pharmacists.
2. The coordination of the patient's care, monitoring, and patient education should ideally be assisted by a neurologist with specialized training and a neurology specialty nurse, who would also keep the other team members informed of any findings and problems.
3. In addition to helping with appropriate dosing and patient education, the pharmacist should look for possible drug-drug interactions and evaluate whether any medication changes are required. If so, they should coordinate with the clinical staff.
4. A multidisciplinary approach will produce better results.
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